cihr_grants: 163301
This data as json
| external_id | title | project_lead_name | co_researchers | institution | province | country | competition_year | award_amount | program | program_type | theme | research_subject | keywords | abstract | duration | source_url |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 163301 | Granzyme B in Hair Follicle Growth | Granville David J | Granville, David J; McElwee, Kevin J | University of British Columbia | British Columbia | Canada | 200802 | 99927.0 | Catalyst Grant: Skin Diseases and Conditions | Operating Grants | Biomedical | Musculoskeletal Health and Arthritis | Alopecia; Alopecia Areata; Apoptosis; Atherogenesis; Granzyme B; Growth Regulation; Hair Follicles; Hair Growth Cycle | Hair loss is a common and distressing problem which can affect men, women, and children. There are several different types of baldness including androgenetic alopecia, better known as pattern baldness, and alopecia areata, a condition that involves immune cells targeting hair follicles and causing patchy hair loss. Recent research on patients has suggested that there may be a link between having androgenetic alopecia and susceptibility to having a heart attack. The research groups of Dr Granville, an expert on heart disease, and Dr McElwee, an expert on hair loss, have teamed up to look for the biological factors that could link baldness to increased risk of heart disease. Our preliminary investigation has suggested that some rodent models susceptible to heart disease are more likely to develop hair loss while models resistant to heart disease have increased hair growth. Equally, a rodent model of alopecia areata is more likely to have heart problems. Biological factors that cause cell death in heart disease, particularly one called granzyme B, also seem to be expressed in hair follicles. We saw levels of granzyme B increased with the development of alopecia areata. These initial observations suggest granzyme B might be a biological link between heart disease and hair loss. Our proposal involves looking at granzyme B in the skin and how it may alter hair growth. We intend to; 1)determine the expression of granzyme B in hair follicles and how expression changes as hair follicles grow, 2)examine the effects of granzyme B deficiency on normal hair follicle growth, and 3) examine the effects of suppressing granzyme B expression in an alopecia areata disease model. We anticipate that increased granzyme B activity is associated with increased hair loss and suppressing it may inhibit hair loss. It is possible that an increased granzyme B action evident in alopecia may reflect an increased granzyme B mediated activity in heart disease development in the same individual. | 1 yr 0 mth | https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=163301&lang=en |