cihr_grants: 163302
This data as json
| external_id | title | project_lead_name | co_researchers | institution | province | country | competition_year | award_amount | program | program_type | theme | research_subject | keywords | abstract | duration | source_url |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 163302 | The role of Periostin in promoting epithelial-myofibroblast transition and avoidance of apoptosis in cutaneous wound healing | O'Gorman David B | O'Gorman, David B; Dagnino, Lina | Western University (Ontario) | Ontario | Canada | 200802 | 53013.0 | Catalyst Grant: Skin Diseases and Conditions | Operating Grants | Biomedical | Musculoskeletal Health and Arthritis | Epithelial-Mesenchymal Transition; Mouse Model; Myofibroblast; Periostin; Scarring And Fibrosis; Wound Healing | Wound healing abnormalities has been estimated to affect at least 4.5 million people in North America. Normal wound healing is an orderly and efficient process that includes the conversion of cells, commonly referred to as fibroblasts, into myofibroblasts to contract the edges of the wound together. Normally myofibroblasts undergo cell death after the wound is contracted, however in abnormal healing situations such as scarring, myofibroblasts are evident in increased numbers and persist after the wound has healed. In addition to the fibroblasts resident in the dermis, it has recently been suggested that these cells may arise through the conversion of cells in the epidermis into myofibroblasts in the dermis, a process known as epithelial-mesenchymal transition (EMT). EMT occurs in fetal development and cancer cell formation. Recently, the protein Periostin has come under intense scrutiny in cancer research, where it has been shown to promote EMT and enhance tumor cell persistence. We have previously shown that Periostin is transiently expressed during normal skin wound healing and that it persists in scar tissue. This research proposal will address whether Periostin induces EMT and promotes myofibroblast formation from epidermal cells during normal wound healing. We will also investigate whether Periostin can enhance myofibroblast survival in scar tissue. These studies have the potential to identify Periostin a target for therapies to reduce scar formation and other abnormal wound healing conditions. | 1 yr 0 mth | https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=163302&lang=en |