cihr_grants: 170252

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170252	Delineating the role of epigenetic modification of histones in establishing tissue specific gene expression.	Dilworth Jeffrey J	Dilworth, Jeffrey J	Ottawa Hospital Research Institute	Ontario	Canada	200809	686661.0	Operating Grant	Operating Grants	Biomedical	Human Development, Child and Youth Health	Chromatin; Development; Epigenetics; Gene Expression; Myogenesis; Stem Cells	The different cell types within the human body all possess an identical DNA content. However, each cell-type has a specific subset of genes that it expresses which gives rise to its identity. Once a cell becomes committed to a cell lineage, a gene expression profile is established that is put into a memory that can then be passed on to daughter cells. This cellular memory is established through epigenetic modification of chromatin, and is mediated by the polycomb and trithorax groups of proteins. In this proposal, we plan to examine how specific cell types decide which genes are going to be marked by polycomb and trithorax group proteins. Using muscle cell development as a model system, we will examine the role of transcriptional regulators in targeting trithorax group proteins to muscle specific genes. Information gained through these studies will permit us to better understand how different cell types are established during development. This knowledge will allow us to take an informed approach to differentiating cells, and thus facilitate the development of efficient stem cell therapies.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170252&lang=en