cihr_grants: 170340
This data as json
| external_id | title | project_lead_name | co_researchers | institution | province | country | competition_year | award_amount | program | program_type | theme | research_subject | keywords | abstract | duration | source_url |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 170340 | Elucidation of novel mechanisms of glucagon action | Drucker Daniel J | Drucker, Daniel J | Lunenfeld-Tanenbaum Research Institute (Toronto) | Ontario | Canada | 200809 | 737930.0 | Operating Grant | Operating Grants | Biomedical | Nutrition, Metabolism and Diabetes | Intestine; Pancreas; Peptide Hormones; Receptors | Glucagon is a hormone secreted from the pancreas that together with insulin, controls levels of blood sugar through actions on the liver. Excess glucagon action in diabetic subjects underlies the inappropriate increase in blood glucose observed in diabetic subjects-hencing reducing glucagon action is a major goal for development of new agents to treat type 2 diabetes. The proposed studies analyze the consequences of attenuating glucagon action in mice with genetic disruption of the glucagon receptor. The Results of these studies are expected to extend our knowledge about how glucagon works, and to inform us about the likely safety and efficacy of new drugs used to block glucagon action for the treatment of diabetes. | 5 yrs 0 mth | https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170340&lang=en |