cihr_grants: 170401

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170401	The Multiple Cellular Functions of the Hsp90 Molecular Chaperone: The Role of Hsp90 and the Conserved R2TP Complex in Ribosomal RNA Processing	Houry Walid A	Houry, Walid A	University of Toronto	Ontario	Canada	200809	677895.0	Operating Grant	Operating Grants	Biomedical	Cancer Research	Cancer; Cochaperones; Helicases; Hsp90 Molecular Chaperone; Ribosomal Rna Processing; Snorna	Hsp90 is a ubiquitous molecular chaperone that is found in eubacteria and all branches of eukarya. It plays a central role in cellular signaling since it is essential for maintaining the activity of several signaling proteins including steroid hormone receptors and protein kinases. Hsp90 is typically overexpressed in cancer cells and is now the target of novel anti-cancer drugs, some of which are in clinical trials. Our research is currently concentrated on better understanding the functions of Hsp90 in the cell. We had previously identified a novel protein complex that interacts with Hsp90. Recently, we were able to show that the complex allows Hsp90 to modulate ribosome biogenesis. This is a very novel finding that has not been previously described and might have important clinical implications when using drugs to target Hsp90. The proposed project will further explore this novel activity of this essential chaperone.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170401&lang=en