cihr_grants: 170495

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170495	The Role of Endocytic Proteins at Bacteria-Induced Pedestals	Guttman Julian A	Guttman, Julian A	Simon Fraser University (Burnaby, B.C.)	British Columbia	Canada	200809	300000.0	CIHR New Investigator	Salary Programs	Biomedical	Infection and Immunity	Animal Models; Attaching And Effacing Pathogens; Clathrin-Based Endocytosis; Host-Pathogen Interactions; Protein Localization; Rna Interference	Pathogenic E.coli infections are a serious global health concern. During their disease processes, these organisms remain outside of host cells and inject a multitude of pathogenic proteins to commandeer normal cellular functions. A characteristic feature of these diseases involves the generation of host cell protrusions beneath the attached bacteria that results in these microbes rising off the natural surface of the cell onto E.coli generated structures called, pedestals. Surprisingly, I recently found that clathrin, a protein known to internalize particles and other bacteria into cells, is an essential component of pedestals and is required for their generation, thus providing a previously unknown function of this protein. In order to understand the mechanisms involved in the non-internalization functions of clathrin, I will examine the subversion strategies that pathogenic E.coli use to avoid clathrin-based internalization in order to remain extracellular. In addition to understanding the methods used by these bacteria to generate disease, this work will also provide insight into the general mechanisms of controlling particle internalization thus allowing for the design of therapeutics.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170495&lang=en