cihr_grants: 170517
This data as json
| external_id | title | project_lead_name | co_researchers | institution | province | country | competition_year | award_amount | program | program_type | theme | research_subject | keywords | abstract | duration | source_url |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 170517 | Arginine methylase PRMT1 and PRMT6 in cancer and genomic instability. | Richard Stéphane | Richard, Stéphane | CIUSSS de Centre-Ouest-de-l'Ile-de-Montréal-Jewish General | Québec | Canada | 200809 | 877100.0 | Operating Grant | Operating Grants | Biomedical | Cancer Research | Arginine Methylation; Cancer; Cell Cycle Control; Conditional Knockout Mice; Dna Damage Response; Genomic Instability | The detection and repair of DNA damage are vital for cell viability. DNA repair defects lead to DNA translocations, deletions/ mutations, chromosome breakage leading to 'genomic instability' and cancer. Several human genetic disorders are associated with failure to repair DNA including the rare human recessive diseases include ataxia telangiectasia (AT), Nijmegen breakage syndrome (NBS), ataxia telangiectasia like disease (ATLD), Fanconi anemia, and the Bloom, Werner, and Rothmund-Thompson syndromes. We discovered that a protein modification called 'arginine methylation' is necessary to repair damaged DNA. It is known that when we expose ourselves to UV light, for example, we introduce DNA damage in our skin cells and this increases the chances of us developing cancer. We showed previously that cells without the enzymes that deposit arginine methylation accumulate DNA damage and are prone to cancer development. We were the first to show this unique role of arginine methylation and herein we propose to continue these studies. We intend to use a basic science approach to study the role of arginine methylation in the process of repairing DNA damage. Genetic (using mice models) and biochemical approaches will be utilized to define the molecular targets of arginine methylation. What are the targets of the enzymes that deposit the arginine methylation marks required for this role in DNA repair? Our work predicts that if we can inactivate the enzymes that deposit arginine methylation (methylases) this will sensitize cells to radio- and chemotherapeutic agents such that lower doses may be required in the clinic for treatment. | 5 yrs 0 mth | https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170517&lang=en |