cihr_grants: 170521

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170521	Investigating the mechanisms of Nod-like receptor-induced cytokine release and cell death in macrophages	Kim Sung O	Kim, Sung O	Western University (Ontario)	Ontario	Canada	200809	640450.0	Operating Grant	Operating Grants	Biomedical	Infection and Immunity	Caspase; Cell Death; Inflammasome; Lysosome; Macrophage; Mitochondria	Macrophages are key immune cells for detecting and eliminating microbial pathogens. Many pathogens induce macrophage death as a virulence tactic to survive and disseminate within the host. Recent studies have identified a family of intracellular receptors known as the nucleotide-binding domain and leucine-rich repeats(NLRs) which recognize intracellular microbial components. Activation of these receptors in macrophages induces rapid release of key inflammatory cytokines and macrophage cell death. Production of cytokines induces inflammation and is important for limiting microbial infections. However, rapid cell death can cause the spillage of unnecessary inflammatory mediators, resulting in overwhelming local inflammation and tissue damages, and defects in immune system by depleting macrophages. However, detailed mechanisms regarding the process of cytokine release and cell death remains to be investigated. This study is to investigate detailed signaling and molecular mechanisms of cytokine release and cell death, and examine the contribution of macrophage death during bacterial infections. This study will provide valuable and fundamental information on interactions between microbes and the host cells, and provide information on designing novel therapeutic tools for treating various bacterial and viral infections.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170521&lang=en