cihr_grants: 170562
This data as json
| external_id | title | project_lead_name | co_researchers | institution | province | country | competition_year | award_amount | program | program_type | theme | research_subject | keywords | abstract | duration | source_url |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 170562 | Regulatory polymorphisms in apoptosis genes and susceptibility to childhood leukemia | Sinnett Daniel | Sinnett, Daniel | Centre hospitalier universitaire Sainte-Justine (Montréal, Québec) | Québec | Canada | 200809 | 410877.0 | Operating Grant | Operating Grants | Biomedical | Genetics | Apoptosis; Biostatistics; Cancer Genetics; Childhood Leukemia; Electromobility Shift Assays; Gene Expression | Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, but little is known about the cause(s) of this disease. We have shown that the origin of childhood ALL could be explained by the interaction between genetic factors and environmental exposures. Here we propose that the susceptibility (or resistance) to childhood ALL is modified by functional variations in the sequences regulating the expression (promoter) of genes coding for programmed cell death (apoptosis). This hypothesis will be tested by performing genetic studies in ALL children (cases) and healthy individuals (controls). The expected results will provide new knowledge on how genes and the mechanisms of gene regulation lead to disease susceptibility or resistance. In the long term, these findings will allow the development of ALL prevention programs for the population. | 3 yrs 0 mth | https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170562&lang=en |