cihr_grants: 170582

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170582	The OSCILLation for ARDS Treated Early (OSCILLATE) Trial	Meade Maureen O	Meade, Maureen O; Ferguson, Niall D	McMaster University	Ontario	Canada	200809	3791391.0	Randomized Controlled Trials	Randomized Controlled Trials	Clinical	Circulatory and Respiratory Health	Acute Respiratory Distress Syndrome; Critical Care; High Frequency Oscillation; Mechanical Ventilation; Ventilator-Induced Lung Injury	Acute respiratory distress syndrome (ARDS) is a common and catastrophic complication of critical illness related to burns, motor vehicle accidents, or overwhelming infection. ARDS kills 40-70% of affected patients. Patients with ARDS require life support in the form of a ventilator to breathe for them while their lungs heal. Ironically, ventilators can cause further damage to the lungs. We propose a study comparing 2 methods to protect the lungs from further damage. One method uses standard mechanical ventilators and the other uses a new type of ventilator, called a high frequency oscillator. Building on our experience with a preliminary study that showed that this is feasible, we propose to test whether this high frequency oscillation will reduce the relative risk of dying from ARDS. A total of 1200 patients will be included from 50 intensive care units in Canada and around the world.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170582&lang=en