cihr_grants: 170631

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170631	Hypoxia alters protein balance in muscle cells: any relation with initiation and development of muscle atrophy in COPD?	Debigare Richard	Debigare, Richard	Université Laval	Québec	Canada	200809	225985.0	Operating Grant	Operating Grants	Biomedical	Musculoskeletal Health and Arthritis	Akt; Atrogin-1; Cell Culture; Copd; Hypoxia; Proteasome	Muscle wasting is a significant problem in chronic obstructive pulmonary disease (COPD) which is associated with important clinical issues such as decreased functional status, reduced quality of life and increased mortality rate. Although accumulating knowledge reveals that contractile protein degradation is the primary mechanism involved in muscle wasting, factors initiating this process in COPD is still poorly understood. Low blood oxygen levels frequently presents in COPD increasing in severity as the disease progress. Lack of oxygen has been suggested to have the potential to trigger muscle loss in human subjects. In a model of cultured muscle cells, we found that low oxygen levels altered contractile protein homeostasis with a net loss in protein content as a consequence. In this research application, we propose to investigate the relationship between low oxygen levels and inflammation in the initiation of contractile protein degradation and the development of muscle atrophy. Greater understanding of the biochemical mechanisms that are involved in peripheral muscle wasting is important to design successful therapies aimed at reversing or stopping its progression and minimizing its adverse effects.	3 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170631&lang=en