cihr_grants: 170657

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170657	Mechanism of Action of the Adenovirus Death Protein E4orf4	Branton Philip E	Branton, Philip E	McGill University	Québec	Canada	200809	720706.0	Operating Grant	Operating Grants	Biomedical	Cancer Research	Adenovirus; Cancer Cells; Cell Cycle; Cell Death; Protein Complexes; Protein Phosphatase 2a	For some time we have used human adenoviruses as models to understand the molecular basis of cancer as such studies have provided many critical insights into processes of importance for cancer. In the present project we have identified an adenovirus protein, E4orf4, that kills cancer cells selectively and leaves normal human cells unaffected. We believe that E4orf4, or drugs that mimic its action, may provide novel avenues for cancer therapy and that if we understand exactly how E4orf4 works that we may be able to develop a drug that mimics its effects. In the present proposal we will examine details of the cancer cell killing specificity of E4orf4, examine the mechanism by which it kills, and begin the process of using this information in drug development.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170657&lang=en