cihr_grants: 170666

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170666	Mechanisms and consequences of three-dimensional (3D) nuclear remodeling of telomeres in cancer	Mai Sabine	Mai, Sabine	University of Manitoba	Manitoba	Canada	200809	388829.0	Operating Grant	Operating Grants	Biomedical	Cancer Research	C-Myc; Genomic Instability; Spectral Karyotyping; Telomere And Interphase Nucleus; Three-Dimensional Imaging; Tumor Initiation	We have previously shown that the structural order of the cell is changed when cells become tumor cells. To document this, we have studied one central component in the cell that is called the nucleus. The nucleus contains our genetic information. The structural order of the nucleus is what differentiates a normal cell from a cancer cell. In other words, if the order of this structure is compromised, the cell is not normal anymore. We propose to identify mechanisms through which the structural organization of the nucleus can be changed. We will define the changes that are required for cells to become cancerous. This study is highly relevant for our understanding of early changes that lead to cancer. In the future, we propose to use the defined changes for the screening of patients at risk of cancer, for monitoring of their disease progression and of treatment success.	3 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170666&lang=en