cihr_grants: 170677

This data as json

external_id	title	project_lead_name	co_researchers	institution	province	country	competition_year	award_amount	program	program_type	theme	research_subject	keywords	abstract	duration	source_url
170677	Mechanism of calpain mediated dopamine loss in PD.	Park David S	Park, David S	University of Ottawa	Ontario	Canada	200809	882625.0	Operating Grant	Operating Grants	Biomedical	Neurosciences, Mental Health and Addiction	Calpains; Cdk5; Dna Damage; Dopamine; Neuronal Death; Parkinsons Disease; Substantia Nigra	Parkinsons disease is a progressive neurodegenerative disorder characterized by loss of specialized brain cells which produce the brain molecule dopamine. Loss of these cells results in impaired movement which is one of the significant, although not exclusive, symptoms of the disease. Recent efforts in this field have focused on understanding the regulatory processes which control this type of death. We have recently shown that a specific protease called calpains may participate in this process. The present research is geared towards determining the causal nature of calpains in this process and determining how calpains mediate this degeneration. In understanding these pathways, we hope to, not only gain an appreciation for an important basic biological process, but also devise therapeutic strategies to treat Parkinsons disease.	5 yrs 0 mth	https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=170677&lang=en